Optimizing a chord means finding a chord inversion and octave position that minimizes left hand changes from the previous chord.
This is something you could do manually by playing with the INV and the 8ve buttons, but the program can do it a lot faster. Not just for a single chord, but also for the entire song or for a range of chords. See Operations on Selected Chords.
Optimizing a chord does not mean it will sound nicer in the context of a song, that is a subjective judgment. It simply means that it will be easier to play the chord given the chord that precedes it.
When a chord is optimized it gets an optimization score:

The score reflects the cumulative number of keys the fingers of the left hand will have to travel to change from the previous chord.
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